Wired, racing heart, irritable

Five people said hydroxyzine and similar antihistamines helped: one said that with the right dosing their symptoms were almost negligible, another said it calmed their system, eased irritability and cleared their mind, and another used it to manage pain. One person also took montelukast and levocetirizine after ejaculating and planned to take hydroxyzine beforehand. Hydroxyzine is a prescription drug; these are personal reports, so talk to a doctor first.

Two people said a cold shower after ejaculation made their symptoms less severe, and one also took 2000 mg of vitamin C, which helped them get through the worst of it. Neither named the specific symptoms. Personal reports only — check with a doctor before taking supplements.

Two people said eating this way helped: one found a low-glutamate diet very helpful, another said their mood is steadier and calmer while in ketosis. The diet meant low carbs, no dairy, and avoiding high-glutamate foods such as MSG, soy sauce and aged cheese.

Two people mentioned taking NAC after orgasm: one said NAC alone helped for a while, and another described methylated B vitamins before orgasm and NAC afterwards, aimed at too much glutamate. No doses or frequency were given. Personal reports — check with a doctor before taking supplements.

Two people said taurine helped: one had two ejaculations in a weekend without trouble, having previously had mood swings afterwards when adding CBD, and another took it with NAC and said earlier problems went away. Commonly mentioned amounts were 3 g a day, or 2–3 g about an hour before orgasm. Personal reports — check with a doctor before taking high doses of supplements.

Two people said taurine worked for them: one took about 1 g before orgasm, and another took 900 mg three to four times a day and said it keeps their mind at peace. Personal reports — check with a doctor before taking supplements.

Two people gave positive feedback: one used clonazepam for palpitations and other symptoms and said it was the only thing that helped in 30 years; the other comment said they had been symptom-free since abstaining for a while. Neither gave a dose or timing.

One person said their heart started racing about an hour after orgasm, with palpitations for around 30 minutes, and they think loratadine got rid of that. One person's experience — check with a doctor before taking medication.

One person said heavy weight lifting keeps their heart rate low during a flare. They didn't say how often or how hard they trained.

One person said they used to get borderline psychotic after orgasm; after more than a week of taking taurine regularly through the day, two orgasms left them feeling odd for only a few hours instead of several days, and they felt the most stable in a long time. A single account. Personal report only — talk to a doctor before taking supplements.

One person said that longer sessions of edging before finishing reduced how severe their symptoms were. They didn't say which symptoms or how long the sessions lasted.

One person said L-dopa from mucuna pruriens helped, without saying which symptoms improved or the dose. Personal report only — check with a doctor before taking supplements.

One person said phenibut eliminated all their symptoms, without naming them or giving a dose or schedule. This is a personal report flagged as high-risk — talk to a doctor before using a psychoactive drug.

One person said CBD, ginger and taurine all worked for them, and they believe all three lower glutamate, so they took CBD to calm an over-excited nervous system. No dose was given. Personal report only — it's best to ask a doctor before trying it.

One person listed fasoracetam, a drug-like nootropic compound, among the things that helped them, with no further detail. Personal report only — the risks of such compounds are unclear, so talk to a doctor first.

One person said that taking 750 mg of GABA after orgasm eased their irritability. Only this one person mentioned it. Personal report only — talk to a doctor before taking supplements.

One person mentioned in passing that ginger had worked for them, without saying in what form, how much or when.

One person said CBD, ginger and niacin all helped them, and they believe all three lower glutamate. No dose or timing was given for ginger. Personal report only — talk to a doctor before taking supplements.

One person said hemp tea gave them good results against POIS, with no further detail. Only this one person mentioned it.

One person said a combination of low-dose ketamine and niacin works for them, though they were still working out the right ratio. No doses, schedule or final protocol were given. Personal report only and high-risk — talk to a doctor before using medication or supplements.

One person said they started a low-glutamate, low-histamine diet last week and it is working well so far. They had to give up a lot of foods they used to eat, but the difference makes it feel worthwhile.

One person who gets an over-excited, wired reaction after orgasm said taking NAC with glycine afterwards worked for them, and seemed to calm that surge down. No doses were given.

One person said phenibut helps a bit but is addictive. They gave no dose or schedule. Personal report only — this drug carries a risk of dependence, so talk to a doctor before using it.

One person said that after going into full abstinence in early March, with no sexual activity and no ejaculation, they felt almost like their pre-POIS self again. A single personal report.